Srimad-bhagavatam Canto 1, Introduction, Srila Prabhupada said:

“The Lord taught the Gosvami about devotional service, comparing it to a creeper, and advised him to protect the bhakti creeper most carefully against the mad elephant offense against the pure devotees.”

Sri Caitanya-caritamrita-Madhya-lila-lila 19.156,

“If the devotee commits an offense at the feet of a Vaisnava while cultivating the creeper of devotional service in the material world, his offense is compared to a mad elephant that uproots the creeper and breaks it. In this way the leaves of the creeper are dried up.”

PURPORT:  

One’s devotional attitude increases in the association of a Vaisnava: By his personal example, Naratama dasa Thakura stresses that a devotee must always remember to please his predecessor acharyas^. The Gosvamis^[1] are represented by one’s spiritual master. One cannot be an acharya (spiritual master) without following strictly in the disciplic succession of the acharyas.  One who is actually serious about advancing in devotional service should desire only to satisfy the previous acharyas.

One should always think of oneself as a servant of the servant of the acharyas, and thinking this, one should live in the society of Vaisnavas [Sri Caitanya-caritamrita-Madhya-lila 13.8]. However, if one thinks that he has become very mature and can live separate from the association of Vaisnavas and thus gives up all the regulative principles due to offending a Vaisnava, one’s position becomes very dangerous. Offenses against the holy name are explained in,

Adi-lila, Chapter Eight, verse 24,

“Giving up the regulative principles and living according to one’s whims is compared to a mad elephant, which by force uproots the bhakti-lata and breaks it to pieces. In this way the bhakti-lata shrivels up.”

Such an offense is especially created when one disobeys the instructions of the spiritual master. This is called guru-avajna. The devotee must therefore be very careful not to commit offenses against the spiritual master by disobeying his instructions. As soon as one is deviated from the instructions of the spiritual master, the uprooting of the bhakti-lata begins, and gradually all the leaves dry up.

Srimad-bhagavatam Canto 1, Introduction, Srila Prabhupada said:

“The Lord taught the Gosvami about devotional service, comparing it to a creeper, and advised him to protect the bhakti creeper most carefully against the mad elephant offense against the pure devotees.”

Sri Caitanya-caritamrita-Madhya-lila-lila 19.156,

“If the devotee commits an offense at the feet of a Vaisnava while cultivating the creeper of devotional service in the material world, his offense is compared to a mad elephant that uproots the creeper and breaks it. In this way the leaves of the creeper are dried up.”

PURPORT:  

One’s devotional attitude increases in the association of a Vaisnava: By his personal example, Naratama dasa Thakura stresses that a devotee must always remember to please his predecessor acharyas^. The Gosvamis^[1] are represented by one’s spiritual master. One cannot be an acharya (spiritual master) without following strictly in the disciplic succession of the acharyas.  One who is actually serious about advancing in devotional service should desire only to satisfy the previous acharyas.

One should always think of oneself as a servant of the servant of the acharyas, and thinking this, one should live in the society of Vaisnavas [Sri Caitanya-caritamrita-Madhya-lila 13.8]. However, if one thinks that he has become very mature and can live separate from the association of Vaisnavas and thus gives up all the regulative principles due to offending a Vaisnava, one’s position becomes very dangerous. Offenses against the holy name are explained in,

Adi-lila, Chapter Eight, verse 24,

“Giving up the regulative principles and living according to one’s whims is compared to a mad elephant, which by force uproots the bhakti-lata and breaks it to pieces. In this way the bhakti-lata shrivels up.”

Such an offense is especially created when one disobeys the instructions of the spiritual master. This is called guru-avajna. The devotee must therefore be very careful not to commit offenses against the spiritual master by disobeying his instructions. As soon as one is deviated from the instructions of the spiritual master, the uprooting of the bhakti-lata begins, and gradually all the leaves dry up.

Srimad-bhagavatam 5.1.5 Purport:

According to Srila Visvanatha Cakravarti Thakura, there are two kinds of impediments to devotional service. The first is an offense at the lotus feet of a Vaisnava. This is called vaisnava-aparadha. Sri Caitanya Mahaprabhu warned His devotees not to commit vaisnava-aparadha, which He described as the mad elephant offense. When a mad elephant enters a beautiful garden, it destroys everything, leaving a barren field. Similarly, the power of vaisnava-aparadha is so great that even an advanced devotee becomes almost devoid of his spiritual assets if he commits it.”

Srimad-bhagavatam 5.10.24 Purport:

Sri Caitanya Mahaprabhu has said that by offending a Vaisnava, one finishes all his spiritual activities. Offending a Vaisnava is considered the mad elephant offense. A mad elephant can destroy an entire garden which has been developed with great labor. One may attain the topmost platform of devotional service, but somehow or other if he offends a Vaisnava, the whole structure collapses.

Sri Caitanya-caritamrita-Madhya-lila-lila 10.156, Purport:

Offenses against the holy name are explained in Adi-lila, Chapter Eight, verse 24.

“Giving up the regulative principles and living according to one’s whims is compared to a mad elephant, which by force uproots the bhakti-lata and breaks it to pieces. In this way the bhakti-lata shrivels up. Such an offense is especially created when one disobeys the instructions of the spiritual master. This is called guru-avajna.”

From the above references, it can be understood that Srila Prabhupada left us plenty of information that explains clearly the consequences of not following, or discounting, and disregarding his orders and instructions.  Moreover, it can be understood that these warnings are applicable to both the regular disciple’s, and the disciples who were charged with leading the Krishna consciousness movement. 

In this regard you should note that ISKCON is suffering with many litigations, and has several factions that have separated from ISKCON.  Moreover, please scrutinize, until you understand, what Srila Prabhupada wrote, in the Srimad-bhagavatam 1.13.15 Purport, in regards to the consequences to the GBC themselves, when they do not follow the orders of Srila Prabhupada.